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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB2
All Species:
17.27
Human Site:
S175
Identified Species:
42.22
UniProt:
O60825
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60825
NP_001018063.1
505
58477
S175
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
N
Chimpanzee
Pan troglodytes
XP_001165887
467
54154
D160
F
V
E
S
V
C
D
D
P
D
V
I
A
A
N
Rhesus Macaque
Macaca mulatta
XP_001082732
471
54341
N167
D
P
D
V
I
A
A
N
I
L
E
V
K
V
S
Dog
Lupus familis
XP_537134
518
59712
S177
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
N
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
S178
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
N
Rat
Rattus norvegicus
Q9JJH5
557
64138
S178
I
L
E
V
K
V
S
S
P
D
Y
P
E
R
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
S238
V
M
E
V
K
L
S
S
P
D
Y
R
G
C
N
Chicken
Gallus gallus
Q91348
470
54386
P163
V
E
S
I
C
D
D
P
A
I
I
E
E
N
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
D156
F
I
E
S
V
C
D
D
P
A
I
I
D
C
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
P152
K
D
I
G
S
T
S
P
D
Y
E
N
S
E
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.8
90.6
94.7
N.A.
89.9
84.1
N.A.
62
60.9
N.A.
N.A.
N.A.
N.A.
N.A.
44.5
N.A.
Protein Similarity:
100
91.6
91.4
95.9
N.A.
94
87.9
N.A.
72.8
75.6
N.A.
N.A.
N.A.
N.A.
N.A.
62.3
N.A.
P-Site Identity:
100
26.6
6.6
100
N.A.
100
100
N.A.
60
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
100
33.3
40
100
N.A.
100
100
N.A.
80
20
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
10
0
10
10
0
0
10
10
0
% A
% Cys:
0
0
0
0
10
20
0
0
0
0
0
0
0
20
0
% C
% Asp:
10
10
10
0
0
10
30
20
10
60
0
0
10
0
0
% D
% Glu:
0
10
70
0
0
0
0
0
0
0
20
10
50
10
0
% E
% Phe:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
40
10
10
10
10
0
0
0
10
10
20
20
0
0
10
% I
% Lys:
10
0
0
0
50
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
0
40
0
0
0
10
0
0
0
10
0
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
10
0
10
70
% N
% Pro:
0
10
0
0
0
0
0
20
70
0
0
40
0
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
40
0
% R
% Ser:
0
0
10
20
10
0
60
50
0
0
0
0
10
0
10
% S
% Thr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% T
% Val:
20
10
0
60
20
40
0
0
0
0
10
10
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
50
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _